Gene

Pawr

Species
Rattus norvegicus
Symbol
Pawr
Name
pro-apoptotic WT1 regulator
Synonyms
  • Par-4
  • par-4 induced by effectors of apoptosis
Biotype
protein coding gene
Automated Description
Enables actin binding activity; protein kinase C binding activity; and protein phosphatase 1 binding activity. Involved in several processes, including detection of stimulus involved in sensory perception of pain; positive regulation of apoptotic process; and regulation of cellular extravasation. Located in actin filament; axon; and neuronal cell body. Biomarker of depressive disorder; epilepsy; middle cerebral artery infarction; and transient cerebral ischemia. Orthologous to human PAWR (pro-apoptotic WT1 regulator).
RGD Description
Enables actin binding activity; protein kinase C binding activity; and protein phosphatase 1 binding activity. Involved in several processes, including detection of stimulus involved in sensory perception of pain; regulation of cellular extravasation; and regulation of muscle system process. Located in actin filament; axon; and neuronal cell body. Biomarker of depressive disorder; middle cerebral artery infarction; transient cerebral ischemia; and visual epilepsy. Orthologous to human PAWR (pro-apoptotic WT1 regulator); PARTICIPATES IN ceramide signaling pathway; INTERACTS WITH (R,R,R)-alpha-tocopherol; (S)-colchicine; 17beta-estradiol.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR15093
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

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      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            mRatBN7.2
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            43.65M43.66M43.67M43.68M43.69M43.70M43.71M43.72M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Pawr molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              Pawr role
              Pawr genetic perturbation
              Interactor gene
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              Interactor role
              Interactor genetic perturbation
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