Version: 8.0.0
Date: Tue Jan 28 2025
Cyp27b1
Rattus norvegicusRGD:69192
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Cyp27b1

Species
Rattus norvegicus
Symbol
Cyp27b1
Name
cytochrome P450, family 27, subfamily b, polypeptide 1
Synonyms
  • 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
  • 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial-like
Biotype
protein coding gene
Automated Description
Enables calcidiol 1-monooxygenase activity. Involved in several processes, including negative regulation of bone trabecula formation; positive regulation of parathyroid hormone secretion; and vitamin D catabolic process. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Used to study Wilson disease; acute kidney failure; nephrosis; and vitamin D-dependent rickets type 1A. Human ortholog(s) of this gene implicated in hepatitis B; obesity; rickets; type 1 diabetes mellitus; and vitamin D-dependent rickets type 1A. Orthologous to human CYP27B1 (cytochrome P450 family 27 subfamily B member 1).
RGD Description
Enables calcidiol 1-monooxygenase activity. Involved in several processes, including negative regulation of bone trabecula formation; positive regulation of parathyroid hormone secretion; and vitamin D catabolic process. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Used to study Wilson disease; acute kidney failure; nephrosis; and vitamin D-dependent rickets type 1A. Human ortholog(s) of this gene implicated in hepatitis B; obesity; rickets; type 1 diabetes mellitus; and vitamin D-dependent rickets type 1A. Orthologous to human CYP27B1 (cytochrome P450 family 27 subfamily B member 1); PARTICIPATES IN steroid biosynthetic pathway; tuberculosis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine; 3,3',4,4',5-pentachlorobiphenyl.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24279
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Cyp27b1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Cyp27b1 role
            Cyp27b1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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