Enables NADH binding activity; aldehyde dehydrogenase (NAD+) activity; and identical protein binding activity. Involved in several processes, including behavioral response to ethanol; cellular response to resveratrol; and response to ischemia. Located in mitochondrial matrix. Used to study metabolic dysfunction and alcohol associated liver disease. Biomarker of heart disease. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; artery disease (multiple); diabetes mellitus (multiple); and liver disease (multiple). Orthologous to human ALDH2 (aldehyde dehydrogenase 2 family member).
RGD Description
Enables NADH binding activity; aldehyde dehydrogenase (NAD+) activity; and identical protein binding activity. Involved in several processes, including behavioral response to ethanol; cellular response to resveratrol; and response to ischemia. Located in mitochondrial matrix. Biomarker of heart disease. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; artery disease (multiple); diabetes mellitus (multiple); and liver disease (multiple). Orthologous to human ALDH2 (aldehyde dehydrogenase 2 family member); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.