Version: 8.1.0
Date: Fri Apr 18 2025
Mre11
Rattus norvegicusRGD:69263
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Mre11

Species
Rattus norvegicus
Symbol
Mre11
Name
MRE11 homolog, double strand break repair nuclease
Synonyms
  • double-strand break repair protein MRE11
  • double-strand break repair protein MRE11A
Biotype
protein coding gene
Automated Description
Predicted to enable 3'-5'-DNA exonuclease activity; identical protein binding activity; and single-stranded DNA endodeoxyribonuclease activity. Predicted to contribute to DNA binding activity and DNA helicase activity. Involved in heart development and host-mediated suppression of symbiont invasion. Located in chromatin; nuclear lumen; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome; ataxia-telangiectasia-like disorder-1; endometrial cancer; gastrointestinal system cancer (multiple); and urinary bladder cancer. Orthologous to human MRE11 (MRE11 homolog, double strand break repair nuclease).
RGD Description
Predicted to enable 3'-5'-DNA exonuclease activity; identical protein binding activity; and single-stranded DNA endodeoxyribonuclease activity. Predicted to contribute to DNA binding activity and DNA helicase activity. Involved in heart development and host-mediated suppression of symbiont invasion. Located in chromatin; nuclear lumen; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome; ataxia-telangiectasia-like disorder-1; endometrial cancer; gastrointestinal system cancer (multiple); and urinary bladder cancer. Orthologous to human MRE11 (MRE11 homolog, double strand break repair nuclease); PARTICIPATES IN altered p53 signaling pathway; ataxia telangiectasia-mutated (ATM) signaling pathway; homologous recombination pathway of double-strand break repair; INTERACTS WITH (+)-pilocarpine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10139
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Mre11 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection method
          Source
          Reference
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            Genetic Interactions

            Mre11 role
            Mre11 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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