Predicted to enable kinase inhibitor activity; protein kinase binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to thyrotropin-releasing hormone; cellular response to type II interferon; and response to progesterone. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Predicted to be located in cytoplasmic ribonucleoprotein granule and nucleoplasm. Biomarker of liver disease (multiple); myocardial infarction; obesity; rheumatic heart disease; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in acute myeloid leukemia; gastrointestinal system cancer (multiple); reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to human SOCS1 (suppressor of cytokine signaling 1).
RGD Description
Predicted to enable kinase inhibitor activity; protein kinase binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to thyrotropin-releasing hormone; cellular response to type II interferon; and response to progesterone. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Predicted to be located in cytoplasmic ribonucleoprotein granule and nucleoplasm. Biomarker of liver disease (multiple); myocardial infarction; obesity; rheumatic heart disease; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in acute myeloid leukemia; gastrointestinal system cancer (multiple); reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to human SOCS1 (suppressor of cytokine signaling 1); PARTICIPATES IN insulin signaling pathway; interleukin-12 signaling pathway; interleukin-2 signaling pathway; INTERACTS WITH 15-deoxy-Delta(12,14)-prostaglandin J2; 17beta-estradiol; 2,2',5,5'-tetrachlorobiphenyl.