Gene

Socs1

Species
Rattus norvegicus
Symbol
Socs1
Name
suppressor of cytokine signaling 1
Synonyms
  • Cish1
  • cytokine inducible SH2-containing protein 1
Biotype
protein coding gene
Automated Description
Predicted to enable kinase inhibitor activity; protein kinase binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to thyrotropin-releasing hormone; cellular response to type II interferon; and response to progesterone. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Predicted to be located in cytoplasmic ribonucleoprotein granule and nucleoplasm. Biomarker of liver disease (multiple); myocardial infarction; obesity; rheumatic heart disease; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in acute myeloid leukemia; gastrointestinal system cancer (multiple); reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to human SOCS1 (suppressor of cytokine signaling 1).
RGD Description
Predicted to enable kinase inhibitor activity; protein kinase binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to thyrotropin-releasing hormone; cellular response to type II interferon; and response to progesterone. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Predicted to be located in cytoplasmic ribonucleoprotein granule and nucleoplasm. Biomarker of liver disease (multiple); myocardial infarction; obesity; rheumatic heart disease; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in acute myeloid leukemia; gastrointestinal system cancer (multiple); reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to human SOCS1 (suppressor of cytokine signaling 1); PARTICIPATES IN insulin signaling pathway; interleukin-12 signaling pathway; interleukin-2 signaling pathway; INTERACTS WITH 15-deoxy-Delta(12,14)-prostaglandin J2; 17beta-estradiol; 2,2',5,5'-tetrachlorobiphenyl.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10155
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
4.8826M4.8828M4.8830M4.8832M4.8834M4.8836M4.8838M4.8840M4.8842M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions