Gene

Cdh2

Species
Rattus norvegicus
Symbol
Cdh2
Name
cadherin 2
Synonyms
  • cadherin 2 type 1 N-cadherin (neuronal)
  • cadherin 2, type 1, N-cadherin (neuronal)
Biotype
protein coding gene
Automated Description
Enables beta-catenin binding activity; nitric-oxide synthase binding activity; and protein tyrosine kinase binding activity. Involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; regulation of Rho protein signal transduction; and regulation of myelination. Located in several cellular components, including T-tubule; adherens junction; and fascia adherens. Part of protein-containing complex. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in agenesis of corpus callosum, cardiac, ocular, and genital syndrome; arrhythmogenic right ventricular cardiomyopathy; and arrhythmogenic right ventricular dysplasia 14. Orthologous to human CDH2 (cadherin 2).
RGD Description
Enables beta-catenin binding activity; nitric-oxide synthase binding activity; and protein tyrosine kinase binding activity. Involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; regulation of Rho protein signal transduction; and regulation of myelination. Located in several cellular components, including T-tubule; adherens junction; and fascia adherens. Part of protein-containing complex. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in agenesis of corpus callosum, cardiac, ocular, and genital syndrome; arrhythmogenic right ventricular cardiomyopathy; and arrhythmogenic right ventricular dysplasia 14. Orthologous to human CDH2 (cadherin 2); PARTICIPATES IN cadherin mediated signaling pathway; fibroblast growth factor signaling pathway; N-cadherin signaling pathway; INTERACTS WITH (+)-pilocarpine; 1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane; 1,3-dinitrobenzene.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24027
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
7.78M7.80M7.82M7.84M7.86M7.88M7.90M7.92M7.94M7.96M7.98M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

8 interactor genes based on 8 annotations
Cdh2 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
Ctnnb1Rattus norvegicus
protein
  • anti bait coimmunoprecipitation
PMID:22106313
protein
Gja1Rattus norvegicus
protein
  • anti bait coimmunoprecipitation
PMID:19509333
protein
Grip1Rattus norvegicus
protein
  • affinity chromatography technology
PMID:15750591
protein
Ppfia1Rattus norvegicus
protein
  • affinity chromatography technology
PMID:15750591
protein
PtprfRattus norvegicus
protein
  • affinity chromatography technology
PMID:15750591
protein
PtprmRattus norvegicus
protein
  • affinity chromatography technology
PMID:9531566
protein
RNF207Homo sapiens
protein
  • affinity chromatography technology
PMID:35352799
protein
UbcRattus norvegicus
protein
  • affinity chromatography technology
PMID:22871113
Showing 1 - 8 of 8 rows
per page

Genetic Interactions

No data available