Version: 8.0.0
Date: Tue Jan 28 2025
Nr2f2
Rattus norvegicusRGD:69305
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Nr2f2

Species
Rattus norvegicus
Symbol
Nr2f2
Name
nuclear receptor subfamily 2, group F, member 2
Synonyms
  • apolipoprotein A-I regulatory protein 1
  • apolipoprotein AI regulatory protein 1
Biotype
protein coding gene
Automated Description
Enables sequence-specific DNA binding activity. Involved in positive regulation of systemic arterial blood pressure; regulation of DNA-templated transcription; and response to estradiol. Predicted to be located in cytosol and nucleoplasm. Used to study hypertension. Human ortholog(s) of this gene implicated in 46,XX sex reversal 5. Orthologous to human NR2F2 (nuclear receptor subfamily 2 group F member 2).
RGD Description
Enables sequence-specific DNA binding activity. Involved in positive regulation of systemic arterial blood pressure; regulation of DNA-templated transcription; and response to estradiol. Predicted to be located in cytosol and nucleoplasm. Used to study hypertension. Human ortholog(s) of this gene implicated in 46,XX sex reversal 5. Orthologous to human NR2F2 (nuclear receptor subfamily 2 group F member 2); PARTICIPATES IN forkhead class A signaling pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24083
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Nr2f2 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Nr2f2 role
            Nr2f2 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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