Gene

Nkx6-1

Species
Rattus norvegicus
Symbol
Nkx6-1
Name
NK6 homeobox 1
Synonyms
  • homeobox protein NK-6 homolog A
  • homeobox protein Nkx-6.1
Biotype
protein coding gene
Automated Description
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including positive regulation of insulin secretion; type B pancreatic cell development; and type B pancreatic cell proliferation. Predicted to be active in nucleus. Orthologous to human NKX6-1 (NK6 homeobox 1).
RGD Description
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including positive regulation of insulin secretion; type B pancreatic cell development; and type B pancreatic cell proliferation. Predicted to be active in nucleus. Orthologous to human NKX6-1 (NK6 homeobox 1); PARTICIPATES IN maturity-onset diabetes of the young pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24340
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
7.970M7.971M7.972M7.973M7.974M7.975M7.976M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions