Enables GDP binding activity and GTP binding activity. Predicted to be involved in several processes, including Golgi to plasma membrane transport; protein localization to ciliary membrane; and small GTPase-mediated signal transduction. Predicted to act upstream of or within intraciliary transport; post-Golgi vesicle-mediated transport; and smoothened signaling pathway. Predicted to be located in several cellular components, including cytoskeleton; midbody; and photoreceptor connecting cilium. Predicted to be active in cytoplasm and microtubule cytoskeleton. Human ortholog(s) of this gene implicated in Joubert syndrome and retinitis pigmentosa 83. Orthologous to human ARL3 (ARF like GTPase 3).
RGD Description
Enables GDP binding activity and GTP binding activity. Predicted to be involved in several processes, including Golgi to plasma membrane transport; protein localization to ciliary membrane; and small GTPase-mediated signal transduction. Predicted to act upstream of or within intraciliary transport; post-Golgi vesicle-mediated transport; and smoothened signaling pathway. Predicted to be located in several cellular components, including cytoskeleton; midbody; and photoreceptor connecting cilium. Predicted to be active in cytoplasm and microtubule cytoskeleton. Human ortholog(s) of this gene implicated in Joubert syndrome and retinitis pigmentosa 83. Orthologous to human ARL3 (ADP ribosylation factor like GTPase 3); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.