Version: 8.1.0Date: Fri Apr 18 2025
Gene
Cyp3a9
- Species
- Rattus norvegicus
- Symbol
- Cyp3a9
- Name
- cytochrome P450, family 3, subfamily a, polypeptide 9
- Synonyms
- 3AH15
- Cyp3a13
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable estrogen 16-alpha-hydroxylase activity; retinoic acid 4-hydroxylase activity; and testosterone 6-beta-hydroxylase activity. Involved in several processes, including response to dexamethasone; response to estradiol; and response to estrogen. Predicted to be located in endoplasmic reticulum membrane. Biomarker of liver cirrhosis. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; essential hypertension; and familial Mediterranean fever. Orthologous to several human genes including CYP3A5 (cytochrome P450 family 3 subfamily A member 5).
- RGD Description
- Predicted to enable estrogen 16-alpha-hydroxylase activity; retinoic acid 4-hydroxylase activity; and testosterone 6-beta-hydroxylase activity. Involved in several processes, including response to dexamethasone; response to estradiol; and response to estrogen. Predicted to be located in endoplasmic reticulum membrane. Biomarker of liver cirrhosis. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; essential hypertension; and familial Mediterranean fever. Orthologous to several human genes including CYP3A7-CYP3A51P (CYP3A7-CYP3A51P readthrough) and CYP3A7 (cytochrome P450 family 3 subfamily A member 7); PARTICIPATES IN artemether pharmacokinetics pathway; axitinib pharmacokinetics pathway; carbamazepine pharmacokinetics pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR24302
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr12:16806207...16846428 - (40.22 kb)
- Assembly version
- mRatBN7.2
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.