Species

Rattus norvegicus

Symbol

Akr1c3

Name

aldo-keto reductase family 1, member C3

Synonyms

20 alpha-hydroxysteroid dehydrogenase
20-alpha-HSD

Biotype

protein coding gene

Automated Description

Enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity and aldose reductase (NADPH) activity. Involved in several processes, including cellular response to follicle-stimulating hormone stimulus; cellular response to ketone; and cellular response to peptide hormone stimulus. Acts upstream of or within progesterone metabolic process. Located in cytosol. Biomarker of polycystic ovary syndrome and pre-eclampsia. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; and leukemia. Orthologous to human AKR1C3 (aldo-keto reductase family 1 member C3).

RGD Description

Enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity and aldose reductase (NADPH) activity. Involved in several processes, including cellular response to follicle-stimulating hormone stimulus; cellular response to ketone; and cellular response to peptide hormone stimulus. Acts upstream of or within progesterone metabolic process. Located in cytosol. Biomarker of polycystic ovary syndrome and pre-eclampsia. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; and leukemia. Orthologous to human AKR1C3 (aldo-keto reductase family 1 member C3); PARTICIPATES IN isoprenoid metabolic pathway; acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; INTERACTS WITH (20S)-20-hydroxypregn-4-en-3-one; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1-naphthyl isothiocyanate.

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR11732

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

Function - GO Annotations

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Pathways

No data available

Phenotypes

Primary Sources: None
Other Sources: None

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Disease Associations

Include negative annotationsCases where the expected disease association was NOT found

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Alleles and Variants

Allele/Variant Symbol	Allele Synonyms	Category	Variant	Variant type	Molecular consequence	Has Disease Annotations	Has Phenotype Annotations
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Transgenic Alleles

Species (carrying the transgene)	Allele symbol	Transgenic construct	Expressed components	Knock-down targets	Regulatory regions	Has Disease Annotations	Has Phenotype Annotations
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Models

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Sequence Feature Viewer

Genome location

Chr17:66110963...66127873 + (16.91 kb)

Assembly version

mRatBN7.2

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Data currently unavailable; sequence viewer under construction

Sequence Details

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Expression

Primary Sources

None

Other Sources

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Akr1c3 molecule type	Interactor gene	Interactor species	Interactor molecule type	Detection methods	Source	Reference
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Genetic Interactions

Akr1c3 role	Akr1c3 genetic perturbation	Interactor gene	Interactor species	Interactor role	Interactor genetic perturbation	Interaction type	Phenotype or trait	Source	Reference
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