Version: 8.0.0
Date: Tue Jan 28 2025
Eif2ak1
Rattus norvegicusRGD:70883
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Eif2ak1

Species
Rattus norvegicus
Symbol
Eif2ak1
Name
eukaryotic translation initiation factor 2 alpha kinase 1
Synonyms
  • eukaryotic translation initiation factor 2-alpha kinase 1
  • HCR
Biotype
protein coding gene
Automated Description
Enables eukaryotic translation initiation factor 2alpha kinase activity. Predicted to be involved in several processes, including HRI-mediated signaling; regulation of protein metabolic process; and response to iron ion starvation. Predicted to act upstream of or within several processes, including macrophage differentiation; multicellular organismal-level iron ion homeostasis; and regulation of protein metabolic process. Predicted to be active in cytosol and nucleus. Orthologous to human EIF2AK1 (eukaryotic translation initiation factor 2 alpha kinase 1).
RGD Description
Enables eukaryotic translation initiation factor 2alpha kinase activity. Predicted to be involved in several processes, including HRI-mediated signaling; regulation of protein metabolic process; and response to iron ion starvation. Predicted to act upstream of or within several processes, including macrophage differentiation; multicellular organismal-level iron ion homeostasis; and regulation of protein metabolic process. Predicted to be active in cytosol and nucleus. Orthologous to human EIF2AK1 (eukaryotic translation initiation factor 2 alpha kinase 1); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; hepatitis C pathway; influenza A pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; ammonium chloride.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11042
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
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    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Eif2ak1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Eif2ak1 role
            Eif2ak1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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