Version: 8.1.0
Date: Fri Apr 18 2025
Kynu
Rattus norvegicusRGD:71061
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Kynu

Species
Rattus norvegicus
Symbol
Kynu
Name
kynureninase
Synonyms
  • kynureninase (L-kynurenine hydrolase)
  • L-kynurenine hydrolase
Biotype
protein coding gene
Automated Description
Enables kynureninase activity and pyridoxal phosphate binding activity. Involved in L-tryptophan catabolic process to acetyl-CoA. Predicted to be located in cytosol; mitochondrion; and nucleoplasm. Predicted to be active in cytoplasm. Used to study hypertension. Human ortholog(s) of this gene implicated in hydroxykynureninuria. Orthologous to human KYNU (kynureninase).
RGD Description
Enables kynureninase activity and pyridoxal phosphate binding activity. Involved in L-tryptophan catabolic process to acetyl-CoA. Predicted to be located in cytosol; mitochondrion; and nucleoplasm. Predicted to be active in cytoplasm. Used to study hypertension. Human ortholog(s) of this gene implicated in hydroxykynureninuria. Orthologous to human KYNU (kynureninase); PARTICIPATES IN tryptophan metabolic pathway; kynurenine metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1-benzylpiperazine; 1-naphthyl isothiocyanate.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR14084
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Must provide at least one subject
    Cell color indicative of annotation volume

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Download all Alleles/Variants for all genes of the species

      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Must provide at least one subject
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Kynu molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection method
          Source
          Reference
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            Genetic Interactions

            Kynu role
            Kynu genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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