Version: 8.0.0
Date: Tue Jan 28 2025
Kirrel1
Rattus norvegicusRGD:727883
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Kirrel1

Species
Rattus norvegicus
Symbol
Kirrel1
Name
kirre like nephrin family adhesion molecule 1
Synonyms
  • kin of IRRE like (Drosophila)
  • kin of IRRE like 1
Biotype
protein coding gene
Automated Description
Predicted to enable cell adhesion molecule binding activity and myosin binding activity. Predicted to be involved in cell-cell adhesion; cell-cell junction maintenance; and glomerular filtration. Predicted to act upstream of or within negative regulation of protein phosphorylation; positive regulation of actin filament polymerization; and renal protein absorption. Located in cell projection membrane; cell-cell junction; and membrane raft. Human ortholog(s) of this gene implicated in nephrotic syndrome type 23. Orthologous to human KIRREL1 (kirre like nephrin family adhesion molecule 1).
RGD Description
Predicted to enable cell adhesion molecule binding activity and myosin binding activity. Predicted to be involved in cell-cell adhesion; cell-cell junction maintenance; and glomerular filtration. Predicted to act upstream of or within negative regulation of protein phosphorylation; positive regulation of actin filament polymerization; and renal protein absorption. Located in cell projection membrane; cell-cell junction; and membrane raft. Human ortholog(s) of this gene implicated in nephrotic syndrome type 23. Orthologous to human KIRREL1 (kirre like nephrin family adhesion molecule 1); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 4,4'-diaminodiphenylmethane; aflatoxin B1.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11640
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Kirrel1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Kirrel1 role
            Kirrel1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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