Version: 8.0.0
Date: Tue Jan 28 2025
Micu1
Rattus norvegicusRGD:735033
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Micu1

Species
Rattus norvegicus
Symbol
Micu1
Name
mitochondrial calcium uptake 1
Synonyms
  • calcium binding atopy-related autoantigen 1
  • calcium uptake protein 1, mitochondrial
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including calcium channel inhibitor activity; calcium ion sensor activity; and protein heterodimerization activity. Predicted to be involved in several processes, including calcium ion transport; cellular response to calcium ion starvation; and positive regulation of cristae formation. Predicted to be located in mitochondrial crista junction and mitochondrial intermembrane space. Predicted to be part of uniplex complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in myopathy with extrapyramidal signs. Orthologous to human MICU1 (mitochondrial calcium uptake 1).
RGD Description
Predicted to enable several functions, including calcium channel inhibitor activity; calcium ion sensor activity; and protein heterodimerization activity. Predicted to be involved in several processes, including calcium ion transport; cellular response to calcium ion starvation; and positive regulation of cristae formation. Predicted to be located in mitochondrial crista junction and mitochondrial intermembrane space. Predicted to be part of uniplex complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in myopathy with extrapyramidal signs. Orthologous to human MICU1 (mitochondrial calcium uptake 1); INTERACTS WITH 2,6-dinitrotoluene; 3-chloropropane-1,2-diol; bisphenol A.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12294
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Micu1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Micu1 role
            Micu1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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