Version: 8.1.0
Date: Fri Apr 18 2025
BUD14
Saccharomyces cerevisiaeSGD:S000000069
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

BUD14

Species
Saccharomyces cerevisiae
Symbol
BUD14
Name
BUD site selection
Synonyms
  • YAR014C
Biotype
protein coding gene
Automated Description
Enables protein phosphatase regulator activity. Involved in several processes, including regulation of actin filament organization; regulation of cell cycle process; and regulation of cell shape. Acts upstream of or within mitotic spindle pole body organization. Located in cellular bud neck; cellular bud tip; and incipient cellular bud site. Part of Kelch-containing formin regulatory complex. Is active in nucleus.
SGD Description
Protein phosphatase regulator; subunit of the Bud14p-Glc7p complex that localizes Glc7p to the cell cortex where it activates the dynein/dynactin complex; subunit of the KFRC complex with Kel1p and Kel2p that regulates Bnr1p (formin) to control actin cable assembly, cytokinesis, and polarized growth; involved in spindle pole body size maintenance; involved in bud-site selection; relative distribution to the nucleus increases upon DNA replication stress
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR47775:SF1
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R64-5-1
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          BUD14 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection method
          Source
          Reference
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            Genetic Interactions

            BUD14 role
            BUD14 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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