Gene

PEP1

Species
Saccharomyces cerevisiae
Symbol
PEP1
Name
carboxyPEPtidase Y-deficient
Synonyms
  • VPS10
  • VPT1
Biotype
protein coding gene
Automated Description
Enables signal sequence binding activity. Involved in mitophagy; pexophagy; and protein targeting to vacuole. Located in Golgi apparatus. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to several human genes including SORL1 (sortilin related receptor 1).
SGD Description
Type I transmembrane sorting receptor for multiple vacuolar hydrolases; plays role in post-ER quality control in the Golgi, involved in protein targeting from the endoplasmic reticulum to the vacuole for degradation; cycles between late-Golgi and prevacuolar endosome-like compartments; targeted to vacuole via AP-3 pathway
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12106:SF27
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
Viewer Help
187.0k187.5k188.0k188.5k189.0k189.5k190.0k190.5k191.0k191.5k

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions