Enables signal sequence binding activity. Involved in mitophagy; pexophagy; and protein targeting to vacuole. Located in Golgi apparatus. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to several human genes including SORL1 (sortilin related receptor 1).
SGD Description
Type I transmembrane sorting receptor for multiple vacuolar hydrolases; plays role in post-ER quality control in the Golgi, involved in protein targeting from the endoplasmic reticulum to the vacuole for degradation; cycles between late-Golgi and prevacuolar endosome-like compartments; targeted to vacuole via AP-3 pathway