Gene

HEK2

Species
Saccharomyces cerevisiae
Symbol
HEK2
Name
HEterogeneous nuclear rnp K-like gene
Synonyms
  • KHD1
  • YBL032W
Biotype
protein coding gene
Automated Description
Enables mRNA binding activity. Involved in intracellular mRNA localization; mRNA stabilization; and telomere maintenance via telomerase. Located in P-body and chromosome, telomeric region. Orthologous to human PCBP3 (poly(rC) binding protein 3) and PCBP4 (poly(rC) binding protein 4).
SGD Description
RNA binding protein involved in asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K; increases mRNA stability by binding (CNN)n repeat elements
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10288:SF309
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

          Model name
          Experimental condition
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            Sequence Feature Viewer

            Genome location
            Assembly version
            R64-5-1
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            160.2k160.4k160.6k160.8k161.0k161.2k

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            HEK2 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
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              Genetic Interactions

              HEK2 role
              HEK2 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
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