Version: 8.1.0Date: Fri Apr 18 2025
Gene
SHP1
- Species
- Saccharomyces cerevisiae
- Symbol
- SHP1
- Name
- Suppressor of High-copy PP1
- Synonyms
- UBX1
- YBL058W
- Biotype
- protein coding gene
- Automated Description
- Enables K48-linked polyubiquitin modification-dependent protein binding activity and protein phosphatase regulator activity. Involved in several processes, including macroautophagy; proteasomal protein catabolic process; and sister chromatid biorientation. Located in cytosol and nucleus. Orthologous to several human genes including UBXN2B (UBX domain protein 2B).
- SGD Description
- Substrate adaptor for Cdc48p; ubiquitin regulatory X (UBX) and Ub-associated (UBA) domain-containing protein that acts as a substrate recruiting cofactor; K48-specific Ub chain binding protein involved in ER-associated degradation (ERAD); positively regulates Glc7p protein phosphatase activity to promote growth and mitotic progression in complex with Cdc48p; regulated by nuclear Ub-dependent degradation (INMAD pathway) independent of the Asi and Doa10 complexes; homolog of human p47 (NSFL1C)
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR23333:SF20
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Sequence Feature Viewer
- Genome location
- ChrII:111437...112708 + (1.27 kb)
- Assembly version
- R64-5-1
- Viewer Help
Data currently unavailable; sequence viewer under construction