Version: 8.1.0
Date: Fri Apr 18 2025
PKC1
Saccharomyces cerevisiaeSGD:S000000201
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

PKC1

Species
Saccharomyces cerevisiae
Symbol
PKC1
Name
Protein Kinase C
Synonyms
  • CLY15
  • CLY5
Biotype
protein coding gene
Automated Description
Enables diacylglycerol-dependent serine/threonine kinase activity. Involved in several processes, including cellular bud neck septin ring organization; pexophagy; and positive regulation of cytoplasmic mRNA processing body assembly. Located in several cellular components, including cytoplasmic stress granule; cytoskeleton; and site of polarized growth. Human ortholog(s) of this gene implicated in several diseases, including autoimmune lymphoproliferative syndrome type 3; carcinoma (multiple); high grade glioma (multiple); spinocerebellar ataxia type 14; and steatotic liver disease. Orthologous to several human genes including PRKCA (protein kinase C alpha); PRKCB (protein kinase C beta); and PRKCD (protein kinase C delta).
SGD Description
Protein serine/threonine kinase; essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24356:SF403
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R64-5-1
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          PKC1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection method
          Source
          Reference
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            Genetic Interactions

            PKC1 role
            PKC1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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