Enables succinate-semialdehyde dehydrogenase [NAD(P)+] activity. Involved in cellular response to oxidative stress; gamma-aminobutyrate shunt; and gamma-aminobutyric acid catabolic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in succinic semialdehyde dehydrogenase deficiency. Orthologous to human ALDH5A1 (aldehyde dehydrogenase 5 family member A1).
SGD Description
Succinate semialdehyde dehydrogenase; involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm