Version: 8.0.0Date: Tue Jan 28 2025
Gene
CKS1
- Species
- Saccharomyces cerevisiae
- Symbol
- CKS1
- Name
- Cdc28 Kinase Subunit
- Synonyms
- YBR135W
- Biotype
- protein coding gene
- Automated Description
- Enables histone binding activity; protein kinase activator activity; and ubiquitin binding activity. Involved in positive regulation of transcription by RNA polymerase II and regulation of mitotic cell cycle. Located in cytoplasm and nucleus. Part of cyclin-dependent protein kinase holoenzyme complex. Used to study breast cancer; liver cancer; and lung cancer. Orthologous to several human genes including CKS2 (CDC28 protein kinase regulatory subunit 2).
- SGD Description
- Cyclin-dependent protein kinase regulatory subunit and adaptor; interacts with Cdc28p (aka Cdk1p); required for G1/S and G2/M phase transitions and budding; mediates phosphorylation and degradation of Sic1p; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters; human homologs CKS1B and CKS2 can each complement yeast cks1 null mutant
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR23415:SF29
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- ChrII:504854...505306 + (0.45 kb)
- Assembly version
- R64-5-1
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.