Version: 8.0.0
Date: Tue Jan 28 2025
MEC1
Saccharomyces cerevisiaeSGD:S000000340
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

MEC1

Species
Saccharomyces cerevisiae
Symbol
MEC1
Name
Mitosis Entry Checkpoint
Synonyms
  • ESR1
  • RAD31
Biotype
protein coding gene
Automated Description
Enables protein kinase activity. Involved in DNA metabolic process; positive regulation of DNA-templated DNA replication; and signal transduction in response to DNA damage. Located in nucleus. Used to study several diseases, including Seckel syndrome; ataxia telangiectasia; colon cancer; endometrial cancer; and non-Hodgkin lymphoma. Human ortholog(s) of this gene implicated in Seckel syndrome (multiple); gastrointestinal system cancer (multiple); lung cancer; and pancreatic cancer. Orthologous to human ATR (ATR serine/threonine kinase).
SGD Description
Genome integrity checkpoint protein and PI kinase superfamily member; Mec1p and Dun1p function in same pathway to regulate dNTP pools and telomere length; signal transducer required for cell cycle arrest and transcriptional responses to damaged or unreplicated DNA; facilitates replication fork progression and regulates P-body formation under replication stress; promotes interhomolog recombination by phosphorylating Hop1p; associates with shortened, dysfunctional telomeres
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11139:SF69
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R64-5-1
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          MEC1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            MEC1 role
            MEC1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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