Version: 8.1.0Date: Fri Apr 18 2025
Gene
IRA1
- Species
- Saccharomyces cerevisiae
- Symbol
- IRA1
- Name
- Inhibitory Regulator of the RAS-cAMP pathway
- Synonyms
- GLC1
- PPD1
- Biotype
- protein coding gene
- Automated Description
- Enables GTPase activator activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and negative regulation of Ras protein signal transduction. Located in membrane. Used to study neurofibromatosis and neurofibromatosis 1. Human ortholog(s) of this gene implicated in several diseases, including Watson syndrome; autistic disorder; hematologic cancer (multiple); neurofibromatosis (multiple); and peripheral nervous system neoplasm (multiple). Orthologous to human NF1 (neurofibromin 1).
- SGD Description
- GTPase-activating protein; negatively regulates RAS by converting it from GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; mutations cause catalase T deficiency, defective glycogen synthesis and defective trehalose accumulation; IRA1 has a paralog, IRA2, that arose from the whole genome duplication; defects in human homolog NF1 are associated with neurofibromatosis
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR10194:SF141
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Sequence Feature Viewer
- Genome location
- ChrII:517350...526628 - (9.28 kb)
- Assembly version
- R64-5-1
- Viewer Help
Data currently unavailable; sequence viewer under construction