Gene

SMY2

Species
Saccharomyces cerevisiae
Symbol
SMY2
Name
Suppressor of MYo2-66
Synonyms
  • YBR172C
Biotype
protein coding gene
Automated Description
Involved in several processes, including endoplasmic reticulum to Golgi vesicle-mediated transport; nuclear protein quality control by the ubiquitin-proteasome system; and regulation of transcription by RNA polymerase II. Located in endoplasmic reticulum membrane. Is active in nucleus. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to several human genes including GIGYF1 (GRB10 interacting GYF protein 1).
SGD Description
GYF domain protein; involved in COPII vesicle formation; regulates Cdc48p function in transcription stress response; interacts with the Sec23p/Sec24p subcomplex; overexpression suppresses the temperature sensitivity of a myo2 mutant; homologous to human GIGYF1 and GIGYF2; similar to S. pombe Mpd2; SMY2 has a paralog, SYH1, that arose from the whole genome duplication
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR14445:SF36
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
Viewer Help
579.2k579.4k579.6k579.8k580.0k580.2k580.4k580.6k580.8k581.0k581.2k

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions