Involved in several processes, including endoplasmic reticulum to Golgi vesicle-mediated transport; nuclear protein quality control by the ubiquitin-proteasome system; and regulation of transcription by RNA polymerase II. Located in endoplasmic reticulum membrane. Is active in nucleus. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to several human genes including GIGYF1 (GRB10 interacting GYF protein 1).
SGD Description
GYF domain protein; involved in COPII vesicle formation; regulates Cdc48p function in transcription stress response; interacts with the Sec23p/Sec24p subcomplex; overexpression suppresses the temperature sensitivity of a myo2 mutant; homologous to human GIGYF1 and GIGYF2; similar to S. pombe Mpd2; SMY2 has a paralog, SYH1, that arose from the whole genome duplication