Version: 8.0.0
Date: Tue Jan 28 2025
FZO1
Saccharomyces cerevisiaeSGD:S000000383
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

FZO1

Species
Saccharomyces cerevisiae
Symbol
FZO1
Name
FuZzy Onions homolog
Synonyms
  • YBR179C
Biotype
protein coding gene
Automated Description
Enables GTPase activity and peroxisome-mitochondrion membrane tether activity. Involved in mitochondrial fusion. Acts upstream of or within intracellular distribution of mitochondria. Located in mitochondrial outer membrane. Is active in peroxisomal-mitochondrial contact site and peroxisome. Used to study Charcot-Marie-Tooth disease type 2A2A and Charcot-Marie-Tooth disease type 2A2B. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; Charcot-Marie-Tooth disease type 2A2A; Charcot-Marie-Tooth disease type 2A2B; Charcot-Marie-Tooth disease type 6; and multiple symmetric lipomatosis. Orthologous to human MFN1 (mitofusin 1) and MFN2 (mitofusin 2).
SGD Description
Mitofusin, involved in mitochondrial outer membrane fusion; mediates contacts between mitochondria and peroxisomes that regulate mitochondrial fusion; GTPase domain is required for auto-oligomerization and for efficient tethering, homotypic fusion and degradation of Fzo1p; role in mitochondrial genome maintenance; targeted for destruction by SCF-Mdm30p and the cytosolic ubiquitin-proteasome system; activity regulated by ubiquitination at conserved lysines and by deubiquitinases Ubp2p and Ubp12p
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10465:SF0
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R64-5-1
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          FZO1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            FZO1 role
            FZO1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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