Gene

GPX2

Species
Saccharomyces cerevisiae
Symbol
GPX2
Name
Glutathione PeroXidase
Synonyms
  • AMI1
  • YBR244W
Biotype
protein coding gene
Automated Description
Enables glutathione peroxidase activity and phospholipid-hydroperoxide glutathione peroxidase activity. Involved in cellular response to oxidative stress. Located in cytoplasm. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma; colorectal cancer; and spondylometaphyseal dysplasia Sedaghatian type. Orthologous to human GPX4 (glutathione peroxidase 4).
SGD Description
Phospholipid hydroperoxide glutathione peroxidase; late-acting antioxidant system that decreases mitochondrial ROS production and preserves electron transport chain (ETC) function; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11592:SF78
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
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707.55k707.60k707.65k707.70k707.75k707.80k707.85k707.90k707.95k708.00k

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions