Version: 8.1.0
Date: Fri Apr 18 2025
RGD1
Saccharomyces cerevisiaeSGD:S000000464
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

RGD1

Species
Saccharomyces cerevisiae
Symbol
RGD1
Name
Related GAP Domain
Synonyms
  • YBR260C
Biotype
protein coding gene
Automated Description
Enables GTPase activator activity and phosphatidylinositol phosphate binding activity. Involved in response to acidic pH and response to osmotic stress. Acts upstream of or within actin cytoskeleton organization. Located in actin cortical patch and cellular bud. Orthologous to several human genes including ARHGAP12 (Rho GTPase activating protein 12); ARHGAP15 (Rho GTPase activating protein 15); and ARHGAP27 (Rho GTPase activating protein 27).
SGD Description
GTPase-activating protein (RhoGAP) for Rho3p and Rho4p; involved in repolarization of actin cytoskeleton during adaptation to heat shock stress; phosphorylated by Pkc1p
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23176:SF128
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R64-5-1
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          RGD1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection method
          Source
          Reference
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            Genetic Interactions

            RGD1 role
            RGD1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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