Gene

ILV6

Species
Saccharomyces cerevisiae
Symbol
ILV6
Name
IsoLeucine Valine
Synonyms
  • YCL009C
Biotype
protein coding gene
Automated Description
Enables enzyme regulator activity. Contributes to acetolactate synthase activity. Involved in branched-chain amino acid biosynthetic process. Located in mitochondrial nucleoid. Part of acetolactate synthase complex.
SGD Description
Regulatory subunit of acetolactate synthase; acetolactate synthase catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR31242:SF2
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
abnormal chemical compound accumulation
abnormal vacuolar morphology
decreased chemical compound accumulation
decreased oxidative stress resistance
decreased resistance to chemicals
haploproficient
increased chemical compound accumulation
increased competitive fitness
increased resistance to chemicals
viable
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
R64-5-1
Viewer Help
104.5k104.6k104.7k104.8k104.9k105.0k105.1k105.2k105.3k105.4k105.5k
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
ilv6-V90D,L91F
  • ilv6-(V90D_L91F)
allele
ilv6-G89D
  • ilv6-Gly89Asp
allele
Yes
ilv6-V110Eallele
ilv6-Δ
  • ilv6-delta
allele
Yes
ilv6-N86A
  • ilv6-Asn86Ala
allele
Yes
ilv6-N104H
  • ilv6-Asn104His
allele
Yes
ilv6-A31Tallele
NC_001135.5:g.105210G>Avariant
SNP
  • synonymous variant
NC_001135.5:g.104476G>Avariant
SNP
  • intergenic variant
NC_001135.5:g.105429G>Avariant
SNP
  • synonymous variant
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Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
Viewer Help
104.7k104.8k104.9k105.0k105.1k105.2k105.3k105.4k105.5kYCL009C_id001 (ILV6)YCL009C_id005 (ILV6)YCL008C_id001 (STP22)YCL008C_id002 (STP22)

Sequence Details

Transcript: Mode:
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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

142 interactor genes based on 182 annotations
ILV6 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
ACO1Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:37968396
protein
ALD5Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:37968396
protein
ALT1Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:37968396
protein
ASC1Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:37158240
RNA
BFR1Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:26524240
protein
BRE5Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:20508643
protein
CAF20Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:29775579
protein
CDC20Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:14660704
protein
CHA1Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:37968396
protein
CIR1Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:37968396
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Genetic Interactions

ILV6 role
ILV6 genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
unspecified role
ALG9Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
unspecified role
ALT1Saccharomyces cerevisiae
unspecified role
positive genetic interaction (sensu BioGRID)
  • colony size
PMID:20093466
unspecified role
ALT1Saccharomyces cerevisiae
unspecified role
positive genetic interaction (sensu BioGRID)
  • colony size
PMID:20093466
unspecified role
ALT1Saccharomyces cerevisiae
unspecified role
positive genetic interaction (sensu BioGRID)
  • colony size
PMID:21623372
unspecified role
ASI2Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
unspecified role
ATG8Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
unspecified role
ATG13Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:20093466
unspecified role
ATG13Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:20093466
unspecified role
ATG39Saccharomyces cerevisiae
unspecified role
positive genetic interaction (sensu BioGRID)
  • colony size
PMID:20093466
unspecified role
ATG39Saccharomyces cerevisiae
unspecified role
positive genetic interaction (sensu BioGRID)
  • colony size
PMID:20093466
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