Version: 8.0.0Date: Tue Jan 28 2025
Gene
BUD23
- Species
- Saccharomyces cerevisiae
- Symbol
- BUD23
- Name
- BUD site selection
- Synonyms
- YCR047C
- Biotype
- protein coding gene
- Automated Description
- Enables rRNA (guanine) methyltransferase activity. Involved in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); rRNA (guanine-N7)-methylation; and ribosomal small subunit export from nucleus. Located in nucleolus. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome. Orthologous to human BUD23 (BUD23 rRNA methyltransferase and ribosome maturation factor).
- SGD Description
- Ribosome biogenesis factor; methyltransferase that methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; required for recruitment of Rps2p; functions with DEAH-box RNA helicase Ecm16p; diploid mutant displays random budding pattern; functional homolog of human WBSCR22
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR12734:SF0
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Gene | Association | Disease Qualifier | Disease | Evidence | Source | Based On | References |
|---|---|---|---|---|---|---|---|
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Sequence Feature Viewer
- Genome location
- ChrIII:210718...211545 - (0.83 kb)
- Assembly version
- R64-5-1
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