Version: 8.0.0Date: Tue Jan 28 2025
Gene
GCN4
- Species
- Saccharomyces cerevisiae
- Symbol
- GCN4
- Name
- General Control Nonderepressible
- Synonyms
- AAS101
- AAS3
- Biotype
- protein coding gene
- Automated Description
- Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II-specific DNA-binding transcription factor binding activity; and chromatin binding activity. Involved in several processes, including positive regulation of cellular response to amino acid starvation; protein localization to nuclear periphery; and regulation of transcription by RNA polymerase II. Located in nucleus.
- SGD Description
- bZIP transcriptional activator of amino acid biosynthetic genes; activator responds to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels; contains four upstream open reading frames (uORFs) in 5' untranslated region which regulate translation; participates in sulfur starvation-induced autophagy along with Met4p, but is dispensable
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR11462:SF35
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- ChrV:138918...139763 - (0.85 kb)
- Assembly version
- R64-5-1
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.