Version: 8.0.0
Date: Tue Jan 28 2025
GCD11
Saccharomyces cerevisiaeSGD:S000000827
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

GCD11

Species
Saccharomyces cerevisiae
Symbol
GCD11
Name
General Control Derepressed
Synonyms
  • SUI4
  • YER025W
Biotype
protein coding gene
Automated Description
Enables translation initiation factor activity and translation initiation factor binding activity. Contributes to GTP binding activity and methionyl-initiator methionine tRNA binding activity. Involved in formation of translation preinitiation complex and positive regulation of translational fidelity. Located in cytosol. Part of several cellular components, including eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; and eukaryotic translation initiation factor 2 complex. Used to study MEHMO syndrome; glucose metabolism disease; hypopituitarism; and leukodystrophy. Human ortholog(s) of this gene implicated in MEHMO syndrome. Orthologous to human EIF2S3 (eukaryotic translation initiation factor 2 subunit gamma) and EIF2S3B (eukaryotic translation initiation factor 2 subunit gamma B).
SGD Description
Gamma subunit of the translation initiation factor eIF2; involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met; mutations in human ortholog cause X-linked intellectual disability (XLID) syndrome
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR42854:SF3
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R64-5-1
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          GCD11 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            GCD11 role
            GCD11 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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