Version: 8.0.0Date: Tue Jan 28 2025
Gene
PTP3
- Species
- Saccharomyces cerevisiae
- Symbol
- PTP3
- Name
- Protein Tyrosine Phosphatase
- Synonyms
- YER075C
- Biotype
- protein coding gene
- Automated Description
- Enables protein tyrosine phosphatase activity. Involved in several processes, including cytoplasmic sequestering of protein; negative regulation of cell integrity MAPK cascade; and pheromone response MAPK cascade. Located in nucleus. Is active in cytoplasm. Orthologous to human PTPN7 (protein tyrosine phosphatase non-receptor type 7).
- SGD Description
- Phosphotyrosine-specific protein phosphatase; major role in the pheromone adaptive response through dephosphorylation of the Fus3p MAPK with a minor role by Ptp2p and Msg5p; minor role in the inactivation of Hog1p MAPK during osmolarity sensing with major role by Ptp2p; dephosphorylates and regulates the localization of Hog1p; minor role in the cell wall integrity pathway through tyrosine dephosphorylation of the MAPK Slt2p while Ptp2p plays a major role; localizes to the cytoplasm
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR19134:SF489
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- ChrV:308413...311199 - (2.79 kb)
- Assembly version
- R64-5-1
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.