Gene

SSA4

Species
Saccharomyces cerevisiae
Symbol
SSA4
Name
Stress-Seventy subfamily A
Synonyms
  • YER103W
  • YG107
Biotype
protein coding gene
Automated Description
Enables unfolded protein binding activity. Involved in SRP-dependent cotranslational protein targeting to membrane, translocation and protein folding. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; artery disease (multiple); autoimmune disease of musculoskeletal system (multiple); neurodegenerative disease (multiple); and schizophrenia (multiple). Orthologous to several human genes including HSPA8 (heat shock protein family A (Hsp70) member 8).
SGD Description
Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; translocates to the nucleus under Cd2+ stress to mediate tolerance by regulating VHS1 expression; cytoplasmic protein that concentrates in nuclei upon starvation; member of the HSP70 family; SSA4 has a paralog, SSA3, that arose from the whole genome duplication
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR19375:SF385
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
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Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions