Version: 8.0.0
Date: Tue Jan 28 2025
CHD1
Saccharomyces cerevisiaeSGD:S000000966
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

CHD1

Species
Saccharomyces cerevisiae
Symbol
CHD1
Name
Chromatin organization modifier, Helicase, and DNA-binding domains
Synonyms
  • YER164W
Biotype
protein coding gene
Automated Description
Enables ATP-dependent chromatin remodeler activity; DNA binding activity; and methylated histone binding activity. Involved in several processes, including DNA-templated transcription; double-strand break repair; and regulation of nucleobase-containing compound metabolic process. Located in nucleolar chromatin. Part of SAGA complex and SLIK (SAGA-like) complex. Is active in site of double-strand break. Used to study prostate cancer. Human ortholog(s) of this gene implicated in castration-resistant prostate carcinoma; developmental and epileptic encephalopathy 94; and prostate cancer. Orthologous to several human genes including CHD1 (chromodomain helicase DNA binding protein 1).
SGD Description
Chromatin remodeler that regulates various aspects of transcription; acts in conjunction with Isw1b to regulate chromatin structure, maintain chromatin integrity during transcription elongation by RNAP II by preventing trans-histone exchange over coding regions; component of both SAGA and SLIK complexes; ATPase motor stimulates DNA unwrapping from nucleosomes; contains two chromodomains, a helicase domain and a DNA-binding domain; human ortholog CHD1 is a prostate cancer tumor suppressor
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45623:SF14
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R64-5-1
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          CHD1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            CHD1 role
            CHD1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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