Gene

RAD3

Species
Saccharomyces cerevisiae
Symbol
RAD3
Name
RADiation sensitive
Synonyms
  • REM1
  • YER171W
Biotype
protein coding gene
Automated Description
Enables 5'-3' DNA helicase activity and damaged DNA binding activity. Involved in nucleotide-excision repair; positive regulation of mitotic recombination; and transcription by RNA polymerase II. Part of nucleotide-excision repair factor 3 complex; transcription factor TFIIH core complex; and transcription factor TFIIH holo complex. Used to study Cockayne syndrome; photosensitive trichothiodystrophy; and xeroderma pigmentosum. Human ortholog(s) of this gene implicated in several diseases, including Cockayne syndrome (multiple); carcinoma (multiple); hematologic cancer (multiple); photosensitive trichothiodystrophy (multiple); and xeroderma pigmentosum (multiple). Orthologous to human ERCC2 (ERCC excision repair 2, TFIIH core complex helicase subunit).
SGD Description
5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11472:SF1
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
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527.2k527.4k527.6k527.8k528.0k528.2k528.4k528.6k528.8k529.0k529.2k529.4k

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions