Enables 5'-3' DNA helicase activity and damaged DNA binding activity. Involved in nucleotide-excision repair; positive regulation of mitotic recombination; and transcription by RNA polymerase II. Part of nucleotide-excision repair factor 3 complex; transcription factor TFIIH core complex; and transcription factor TFIIH holo complex. Used to study Cockayne syndrome; photosensitive trichothiodystrophy; and xeroderma pigmentosum. Human ortholog(s) of this gene implicated in several diseases, including Cockayne syndrome (multiple); carcinoma (multiple); hematologic cancer (multiple); photosensitive trichothiodystrophy (multiple); and xeroderma pigmentosum (multiple). Orthologous to human ERCC2 (ERCC excision repair 2, TFIIH core complex helicase subunit).
SGD Description
5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress