Version: 8.1.0Date: Fri Apr 18 2025
Gene
NAM8
- Species
- Saccharomyces cerevisiae
- Symbol
- NAM8
- Name
- Nuclear Accommodation of Mitochondria
- Synonyms
- MRE2
- MUD15
- Biotype
- protein coding gene
- Automated Description
- Enables mRNA binding activity. Involved in mRNA splice site recognition and positive regulation of mRNA splicing, via spliceosome. Located in cytoplasm and nucleus. Part of U1 snRNP; U2-type prespliceosome; and commitment complex. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 26. Orthologous to human TIA1 (TIA1 cytotoxic granule associated RNA binding protein) and TRNAU1AP (tRNA selenocysteine 1 associated protein 1).
- SGD Description
- RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR47640:SF10
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- ChrVIII:278153...279724 + (1.57 kb)
- Assembly version
- R64-5-1
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.