Version: 8.0.0
Date: Tue Jan 28 2025
YNG2
Saccharomyces cerevisiaeSGD:S000001132
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

YNG2

Species
Saccharomyces cerevisiae
Symbol
YNG2
Name
Yeast iNG1 homolog
Synonyms
  • EAF4
  • NBN1
Biotype
protein coding gene
Automated Description
Enables methylated histone binding activity. Contributes to histone acetyltransferase activity. Involved in DNA repair. Located in cytosol and nucleus. Part of NuA4 histone acetyltransferase complex and piccolo histone acetyltransferase complex. Used to study hepatocellular carcinoma; melanoma; and squamous cell carcinoma. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human ING3 (inhibitor of growth family member 3); ING4 (inhibitor of growth family member 4); and ING5 (inhibitor of growth family member 5).
SGD Description
Subunit of NuA4, an essential histone acetyltransferase complex; positions Piccolo NuA4 for efficient acetylation of histone H4 or histone H2A; relocalizes to the cytosol in response to hypoxia; similar to human tumor suppressor ING1 and its isoforms ING4 and ING5
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10333:SF100
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R64-5-1
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          YNG2 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            YNG2 role
            YNG2 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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