Predicted to enable SNARE binding activity; signal sequence binding activity; and zinc ion binding activity. Involved in COPII-coated vesicle cargo loading. Located in cell periphery; endoplasmic reticulum; and mating projection tip. Part of COPII vesicle coat. Human ortholog(s) of this gene implicated in Cole-Carpenter syndrome. Orthologous to several human genes including SEC24D (SEC24 homolog D, COPII coat complex component).
SGD Description
Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat; COPII coat is required for cargo selection during vesicle formation in ER to Golgi transport; scaffolding function of Lst1p required to generate vesicles that can accommodate difficult cargo proteins that include large oligomeric assemblies and asymmetrically distributed membrane proteins; with Atg40p acts in autophagy of the ER; homologous to Sec24p and Sfb2p