Gene

SFB3

Species
Saccharomyces cerevisiae
Symbol
SFB3
Name
Sed Five Binding
Synonyms
  • LST1
  • YHR098C
Biotype
protein coding gene
Automated Description
Predicted to enable SNARE binding activity; signal sequence binding activity; and zinc ion binding activity. Involved in COPII-coated vesicle cargo loading. Located in cell periphery; endoplasmic reticulum; and mating projection tip. Part of COPII vesicle coat. Human ortholog(s) of this gene implicated in Cole-Carpenter syndrome. Orthologous to several human genes including SEC24D (SEC24 homolog D, COPII coat complex component).
SGD Description
Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat; COPII coat is required for cargo selection during vesicle formation in ER to Golgi transport; scaffolding function of Lst1p required to generate vesicles that can accommodate difficult cargo proteins that include large oligomeric assemblies and asymmetrically distributed membrane proteins; with Atg40p acts in autophagy of the ER; homologous to Sec24p and Sfb2p
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13803:SF4
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
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299.5k300.0k300.5k301.0k301.5k

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions