Enables unfolded protein binding activity. Involved in sterol biosynthetic process. Located in cytosol; endoplasmic reticulum; and nucleus. Orthologous to human INSIG1 (insulin induced gene 1) and INSIG2 (insulin induced gene 2).
SGD Description
Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; forms foci at the nuclear periphery upon DNA replication stress; relocalizes to the cytosol in response to hypoxia; homolog of mammalian INSIG proteins; NSG1 has a paralog, NSG2, that arose from the whole genome duplication