Gene

BAT1

Species
Saccharomyces cerevisiae
Symbol
BAT1
Name
Branched-chain Amino acid Transaminase
Synonyms
  • ECA39
  • TWT1
Biotype
protein coding gene
Automated Description
Enables branched-chain-amino-acid transaminase activity. Involved in branched-chain amino acid biosynthetic process and branched-chain amino acid catabolic process. Located in mitochondrial matrix. Human ortholog(s) of this gene implicated in hypervalinemia and hyperleucine-isoleucinemia. Orthologous to several human genes including BCAT2 (branched chain amino acid transaminase 2).
SGD Description
Mitochondrial branched-chain amino acid (BCAA) aminotransferase; preferentially involved in BCAA biosynthesis; homolog of murine ECA39; highly expressed during logarithmic phase and repressed during stationary phase; BAT1 has a paralog, BAT2, that arose from the whole genome duplication
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11825:SF44
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensBCAT29 of 9YesYes   
Homo sapiensBCAT18 of 9NoYes   
Mus musculusBcat29 of 9YesYes   
Mus musculusBcat19 of 9YesYes   
Rattus norvegicusBcat29 of 9YesYes   
Rattus norvegicusBcat19 of 9YesYes   
Xenopus tropicalisbcat25 of 9YesYes   
Danio reriobcat19 of 9YesYes   
Drosophila melanogasterBcat9 of 9YesYes   
Caenorhabditis elegansbcat-19 of 9YesYes   
Caenorhabditis elegansY44A6D.57 of 9NoYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
BAT2137585779 of 9 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
abnormal actin cytoskeleton morphology
auxotrophy
decreased cell size
decreased chemical compound accumulation
decreased duration cell cycle progression in G1 phase
decreased fermentative metabolism
decreased osmotic stress resistance
decreased protein/peptide modification
decreased rate fermentative metabolism
decreased rate vegetative growth
Showing 1 - 10 of 17 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
R64-5-1
Viewer Help
516.8k517.0k517.2k517.4k517.6k517.8k518.0k518.2k518.4k518.6k518.8kBAT1YHR208W_id001YHR208W_id002
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
bat1-Δ
  • bat1-delta
allele
Yes
bat1-G333Wallele
bat1-A234Dallele
Yes
bat1-G333Sallele
NC_001140.6:g.518911T>Cvariant
SNP
  • intergenic variant
NC_001140.6:g.518542C>Gvariant
SNP
  • synonymous variant
NC_001140.6:g.518179C>Tvariant
SNP
  • synonymous variant
NC_001140.6:g.518620A>Gvariant
SNP
  • synonymous variant
NC_001140.6:g.518740C>Tvariant
SNP
  • intergenic variant
NC_001140.6:g.516805T>Cvariant
SNP
  • intergenic variant
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Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
Viewer Help
517.6k517.8k518.0k518.2k518.4k518.6kYHR208W_id001 (BAT1)YHR208W_id002 (BAT1)

Sequence Details

Loading...

Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

129 interactor genes based on 193 annotations
BAT1 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
ACO1Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:26659116
protein
ACO1Saccharomyces cerevisiae
protein
  • protein complementation assay
PMID:26659116
protein
ACO1Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:26659116
protein
ADH3Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:37968396
protein
APE2Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:26659116
protein
APL5Saccharomyces cerevisiae
protein
  • proximity labelling technology
PMID:32840906
protein
APQ12Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:37968396
protein
ATG9Saccharomyces cerevisiae
protein
  • proximity labelling technology
PMID:38958087
protein
BAT1Saccharomyces cerevisiae
protein
  • protein complementation assay
PMID:25841022
protein
BAT1Saccharomyces cerevisiae
protein
  • dihydrofolate reductase reconstruction
PMID:31454312
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Genetic Interactions

BAT1 role
BAT1 genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
unspecified role
ABD1Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
unspecified role
ACE2Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:20093466
enhancer gene
ALD2Saccharomyces cerevisiae
enhanced gene
phenotypic enhancement (sensu BioGRID)
  • chemical compound accumulation
PMID:26721212
enhancer gene
ALD5Saccharomyces cerevisiae
enhanced gene
phenotypic enhancement (sensu BioGRID)
  • chemical compound accumulation
PMID:26721212
enhanced gene
ALD6Saccharomyces cerevisiae
enhancer gene
phenotypic enhancement (sensu BioGRID)
  • chemical compound accumulation
PMID:25280745
unspecified role
ALG3Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:20093466
unspecified role
AME1Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
unspecified role
ARC40Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
unspecified role
ARO1Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:20093466
unspecified role
ARO1Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
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