Gene

IMD2

Species
Saccharomyces cerevisiae
Symbol
IMD2
Name
IMP Dehydrogenase
Synonyms
  • PUR5
  • YHR216W
Biotype
protein coding gene
Automated Description
Enables chromatin binding activity. Predicted to be involved in GTP biosynthetic process. Located in chromatin and cytoplasm. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 11; retinitis pigmentosa; and retinitis pigmentosa 10. Orthologous to several human genes including IMPDH1 (inosine monophosphate dehydrogenase 1).
SGD Description
Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in GTP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation; IMD2 has a paralog, YAR073W/YAR075W, that arose from a segmental duplication
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11911:SF111
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
Viewer Help
554.4k554.6k554.8k555.0k555.2k555.4k555.6k555.8k

Sequence Details

Loading...

Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions