Gene

HOP1

Species
Saccharomyces cerevisiae
Symbol
HOP1
Name
HOmolog Pairing
Synonyms
  • YIL072W
Biotype
protein coding gene
Automated Description
Enables chromatin binding activity and four-way junction DNA binding activity. Involved in activation of reciprocal meiotic recombination; meiotic recombination checkpoint signaling; and synaptonemal complex assembly. Located in lateral element. Orthologous to several human genes including HORMAD1 (HORMA domain containing 1).
SGD Description
Meiosis-specific HORMAD protein required for chromosome synapsis; displays Red1p-dependent localization to unsynapsed axial-lateral elements of the synaptonemal complex; required for chiasma formation; binds chromatin to regulate initiation of meiotic recombination; promotes intra- and intermolecular synapsis between dsDNA molecules and folds DNA into rigid protein-DNA filaments in vitro; contains a HORMA domain, and a chromatin-binding region made up of PHD and winged helix-turn-helix domains
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR48225:SF5
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
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Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions