Version: 8.1.0
Date: Fri Apr 18 2025
HOP1
Saccharomyces cerevisiaeSGD:S000001334
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

HOP1

Species
Saccharomyces cerevisiae
Symbol
HOP1
Name
HOmolog Pairing
Synonyms
  • YIL072W
Biotype
protein coding gene
Automated Description
Enables chromatin binding activity and four-way junction DNA binding activity. Involved in activation of reciprocal meiotic recombination; meiotic recombination checkpoint signaling; and synaptonemal complex assembly. Located in lateral element. Orthologous to several human genes including HORMAD1 (HORMA domain containing 1).
SGD Description
Meiosis-specific HORMAD protein required for chromosome synapsis; displays Red1p-dependent localization to unsynapsed axial-lateral elements of the synaptonemal complex; required for chiasma formation; binds chromatin to regulate initiation of meiotic recombination; promotes intra- and intermolecular synapsis between dsDNA molecules and folds DNA into rigid protein-DNA filaments in vitro; contains a HORMA domain, and a chromatin-binding region made up of PHD and winged helix-turn-helix domains
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR48225:SF5
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R64-5-1
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          HOP1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection method
          Source
          Reference
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            Genetic Interactions

            HOP1 role
            HOP1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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