Enables sphingosine N-acyltransferase activity. Involved in ceramide biosynthetic process. Located in endoplasmic reticulum. Part of acyl-CoA ceramide synthase complex. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 9 and progressive myoclonus epilepsy 8. Orthologous to several human genes including CERS2 (ceramide synthase 2); CERS3 (ceramide synthase 3); and CERS4 (ceramide synthase 4).
SGD Description
Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p; LAC1 has a paralog, LAG1, that arose from the whole genome duplication