Gene

LAC1

Species
Saccharomyces cerevisiae
Symbol
LAC1
Name
Longevity-Assurance gene Cognate (LAG1 Cognate)
Synonyms
  • DGT1
  • YKL008C
Biotype
protein coding gene
Automated Description
Enables sphingosine N-acyltransferase activity. Involved in ceramide biosynthetic process. Located in endoplasmic reticulum. Part of acyl-CoA ceramide synthase complex. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 9 and progressive myoclonus epilepsy 8. Orthologous to several human genes including CERS2 (ceramide synthase 2); CERS3 (ceramide synthase 3); and CERS4 (ceramide synthase 4).
SGD Description
Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p; LAC1 has a paralog, LAG1, that arose from the whole genome duplication
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12560:SF11
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
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Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions