Gene

RAM2

Species
Saccharomyces cerevisiae
Symbol
RAM2
Name
RAS protein and A-factor Maturation
Synonyms
  • YKL019W
Biotype
protein coding gene
Automated Description
Enables CAAX-protein geranylgeranyltransferase activity and protein farnesyltransferase activity. Involved in peptide pheromone maturation; protein farnesylation; and protein geranylgeranylation. Part of CAAX-protein geranylgeranyltransferase complex and protein farnesyltransferase complex. Orthologous to human FNTA (farnesyltransferase, CAAX box, subunit alpha).
SGD Description
Alpha subunit of farnesyltransferase and geranylgeranyltransferase-I; farnesyltransferase (Ram2p-Ram1p heterodimer) catalyzes the addition of 15-carbon isoprenoid farnesyl to substrate proteins containing a CAAX consensus motif; type I geranylgeranyltransferase (Ram2p-Cdc43p heterodimer) catalyzes the addition of the 20-carbon isoprenoid geranylgeranyl to substrate proteins containing a CaaL consensus motif; required for membrane localization of Ras proteins and a-factor
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11129:SF1
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
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402.6k402.7k402.8k402.9k403.0k403.1k403.2k403.3k403.4k403.5k

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions