Gene

CUE2

Species
Saccharomyces cerevisiae
Symbol
CUE2
Name
Coupling of Ubiquitin conjugation to ER degradation
Synonyms
  • YKL090W
Biotype
protein coding gene
Automated Description
Enables RNA endonuclease activity and ubiquitin binding activity. Involved in nuclear-transcribed mRNA catabolic process, no-go decay. Is active in cytosolic ribosome.
SGD Description
Ubiquitin-binding endonuclease involved in mRNA decay; recruited to stalled ribosomes to promote breakdown of transcript body of nuclear-transcribed mRNA with stalls in translation elongation; cleaves mRNA within A site of colliding ribosome; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46535:SF1
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
Viewer Help
272.0k272.2k272.4k272.6k272.8k273.0k273.2k

Sequence Details

Loading...

Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions