Coupling of Ubiquitin conjugation to ER degradation
Synonyms
YKL090W
Biotype
protein coding gene
Automated Description
Enables RNA endonuclease activity and ubiquitin binding activity. Involved in nuclear-transcribed mRNA catabolic process, no-go decay. Is active in cytosolic ribosome.
SGD Description
Ubiquitin-binding endonuclease involved in mRNA decay; recruited to stalled ribosomes to promote breakdown of transcript body of nuclear-transcribed mRNA with stalls in translation elongation; cleaves mRNA within A site of colliding ribosome; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination