Gene

VPS1

Species
Saccharomyces cerevisiae
Symbol
VPS1
Name
Vacuolar Protein Sorting
Synonyms
  • GRD1
  • LAM1
Biotype
protein coding gene
Automated Description
Enables GTPase activity and actin filament binding activity. Involved in several processes, including peroxisome fission; protein localization to organelle; and protein localization to phagophore assembly site. Located in several cellular components, including actin cortical patch; fungal-type vacuole membrane; and late endosome. Is active in phagophore assembly site. Used to study several diseases, including Charcot-Marie-Tooth disease dominant intermediate B; centronuclear myopathy 1; developmental and epileptic encephalopathy; lethal congenital contracture syndrome; and microcytic anemia. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease dominant intermediate B; alopecia areata; avian influenza; centronuclear myopathy 1; and developmental and epileptic encephalopathy (multiple). Orthologous to several human genes including MX1 (MX dynamin like GTPase 1); MX2 (MX dynamin like GTPase 2); and DNM1 (dynamin 1).
SGD Description
Dynamin-like GTPase required for vacuolar sorting; promotes fission of retrograde transport carriers from endosome; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11566:SF21
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

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      Transgenic Alleles

      Species
      (carrying the transgene)
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          R64-5-1
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          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          VPS1 molecule type
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            Genetic Interactions

            VPS1 role
            VPS1 genetic perturbation
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