Version: 8.0.0
Date: Tue Jan 28 2025
DYN1
Saccharomyces cerevisiaeSGD:S000001762
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

DYN1

Species
Saccharomyces cerevisiae
Symbol
DYN1
Name
DYNein
Synonyms
  • DHC1
  • PAC6
Biotype
protein coding gene
Automated Description
Enables ATP binding activity and minus-end-directed microtubule motor activity. Involved in establishment of mitotic spindle orientation; mitotic sister chromatid segregation; and nuclear migration along microtubule. Located in astral microtubule; cell cortex; and spindle pole body. Part of cytoplasmic dynein complex. Used to study Charcot-Marie-Tooth disease axonal type 2O; congenital muscular dystrophy; lissencephaly; polymicrogyria; and spinal muscular atrophy with lower extremity predominant 1. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2O; autosomal dominant intellectual developmental disorder 13; lissencephaly; and spinal muscular atrophy with lower extremity predominant 1. Orthologous to human DYNC1H1 (dynein cytoplasmic 1 heavy chain 1).
SGD Description
Cytoplasmic heavy chain dynein; microtubule motor protein; member of the AAA+ protein family, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p; motility along microtubules inhibited by She1p
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10676:SF314
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R64-5-1
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          DYN1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            DYN1 role
            DYN1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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