Version: 8.0.0Date: Tue Jan 28 2025
Gene
PXL1
- Species
- Saccharomyces cerevisiae
- Symbol
- PXL1
- Name
- PaXillin-Like protein
- Synonyms
- YKR090W
- Biotype
- protein coding gene
- Automated Description
- Enables Rho GDP-dissociation inhibitor activity. Involved in maintenance of cell polarity and regulation of Rho protein signal transduction. Located in several cellular components, including cellular bud tip; incipient cellular bud site; and mating projection tip. Orthologous to human LPXN (leupaxin); PXN (paxillin); and TGFB1I1 (transforming growth factor beta 1 induced transcript 1).
- SGD Description
- Protein that localizes to sites of polarized growth; required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; contains LIM domains and has similarity to metazoan paxillin; relocalizes from bud neck to cytoplasm upon DNA replication stress
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR24216:SF15
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Gene | Association | Disease Qualifier | Disease | Evidence | Source | Based On | References |
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Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- ChrXI:608946...611066 + (2.12 kb)
- Assembly version
- R64-5-1
- Viewer Help
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.