Gene

RIM15

Species
Saccharomyces cerevisiae
Symbol
RIM15
Name
Regulator of IME2
Synonyms
  • TAK1
  • YFL033C
Biotype
protein coding gene
Automated Description
Enables protein serine/threonine kinase activity. Involved in several processes, including cellular response to nitrogen starvation; positive regulation of cell cycle process; and positive regulation of metabolic process. Acts upstream of or within cellular response to hydrogen peroxide. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 108; female breast cancer; mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations; and thrombocytopenia. Orthologous to several human genes including MAST1 (microtubule associated serine/threonine kinase 1); MAST2 (microtubule associated serine/threonine kinase 2); and MAST3 (microtubule associated serine/threonine kinase 3).
SGD Description
Protein kinase involved in cell proliferation in response to nutrients; glucose-repressible; involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; phosphorylates Igo1p and Igo2p; substrate of Pho80p-Pho85p kinase
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24356:SF1
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            R64-5-1
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            69.5k70.0k70.5k71.0k71.5k72.0k72.5k73.0k73.5k74.0k

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            RIM15 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              RIM15 role
              RIM15 genetic perturbation
              Interactor gene
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